• Physician Profile

    Joseph D. Mancias, MD, PhD

    Joseph D. Mancias, MD, PhD
    Assistant Professor of Radiation Oncology, Harvard Medical School


    Radiation Oncology
    Gastrointestinal Cancer

    Office phone: 617-732-6310
    Appointment phone: 617-732-5120
    Fax: 617-732-7347
    Website: The Mancias Lab

    Preferred contact method: appointment phone
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    Radiation Oncology


    Pancreatic cancer, Gastrointestinal cancer

    Dana-Farber Cancer Institute
    450 Brookline Avenue
    Boston, MA 02215


    Dr. Joseph Mancias is a radiation oncologist in the Gastrointestinal Oncology disease center at the Dana-Farber/Brigham and Women's Cancer Center. He specializes in the care of patients with gastrointestinal cancers and runs an independent laboratory at the Dana-Farber Cancer Institute focused on the biology of pancreatic cancer.

    He received his medical and graduate degrees as part of the Tri-Institutional Weill Cornell/Rockefeller/Sloan-Kettering M.D.-Ph.D. Program earning a Ph.D. degree from the Weill Cornell Graduate School of Medical Sciences and his M.D. from Weill Cornell Medical College. He performed his internship in Internal Medicine at Brigham and Women’s Hospital followed by a residency in Radiation Oncology in the combined Harvard Radiation Oncology Program. He subsequently completed a research fellowship in pancreatic cancer biology at Harvard Medical School and Dana-Farber Cancer Institute.

    His research focuses on critical aspects of the biology of pancreatic cancer including selective autophagy, iron metabolism and therapeutic resistance in order to develop novel therapeutic approaches. His lab takes a comprehensive approach combining biochemical, quantitative mass spectrometry-based proteomic, gene editing, cell biological, and advanced modeling techniques to further our understanding of pancreatic cancer.


    Board Certification
    Radiation Oncology

    Harvard Medical School and Dana-Farber Cancer Institute

    Harvard Radiation Oncology Program, Radiation Oncology, 2013

    Brigham and Women's Hospital

    Medical School
    Weill Medical College of Cornell University, 2008

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