• Researcher Profile

    Steven J. Mentzer, MD

     
    Steven J. Mentzer, MD

    Top Doctor

     
    Professor of Surgery, Harvard Medical School

    Centers/Programs

    Thoracic Oncology
    Gastrointestinal Cancer

    Office phone: 617-732-6703
    Fax: 617-730-2898
    Email: smentzer@partners.org

    Preferred contact method: office phone

    View Physician Profile
     
     

    Research Department

    Medical Oncology/Solid Tumor Oncology

    Interests

    Esophageal cancer, Hyperhidrosis and neurogenic tumors, Lung and pleural cancer, Lung transplantation, Mediastinal tumors, Minimally invasive and robotic thoracic surgery

    Area of Research

    Mechanisms of Lymphocyte Recirculation and Recruitment

    Brigham and Women's Hospital
    75 Francis Street
    Boston, MA 02215

    Biography

    Dr. Mentzer received his MD in 1981 from the University of Minnesota. He completed his general surgery training at Brigham and Women's Hospital and his cardiothoracic surgery fellowship at the University of Toronto. He also completed a research fellowship at DFCI, where he investigated the molecular mechanisms involved in the regulation of T lymphocyte function. He is board certified in general surgery, cardiothoracic surgery, and surgical critical care.

    Research

    Mechanisms of Lymphocyte Recirculation and Recruitment

    In the mammalian immune system, cell migration plays an important role in the host defense against a variety of antigenic challenges. Cell migration is the process that delivers lymphocytes to virally infected tissues, organ allografts, or growing tumors. Understanding the mechanism of lymphocyte homing to the site of antigen challenge offers the potential for regulating this process clinically. For example, it would be desirable to enhance lymphocyte migration into virally infected tissues and malignant tumors, but suppress lymphocyte migration into organ allografts.

    In recent years, attempts to define the mechanism of lymphocyte homing to the site of inflammation have focused on cell adhesion molecules. These molecules are expressed on the cell surface and appear to regulate the interaction of lymphocytes with the endothelial cells that line the vessel wall. Our approach was to study the function of these molecules under physiologic conditions both in vitro and in vivo. Using a video microscopy chamber to simulate flow conditions in the inflammatory microcirculation, we studied the contribution of these cell adhesion molecules to lymphocyte movement, adhesion, and locomotion. The regulation of lymphocyte migration can be clarified by selectively inhibiting or augmenting the function of these cell adhesion molecules.

    Cell migration to the site of antigen challenge is a process that involves not only lymphocytes and endothelial cells, but complex microhemodynamic forces as well. The forces at the vessel wall appear to be important determinants of whether cells exit the microcirculation or remain in the flow stream. For example, during lymphocytic inflammation, microhemodynamic forces can vary widely as the microcirculation undergoes dramatic structural adaptation. It is possible that these structural changes facilitate lymphocyte transmigration. To study the effect of microhemodynamic forces on lymphocyte migration, we tracked migrating lymphocytes from the efferent lymph to the antigen-stimulated microcirculation. Using fluorescence and dark-field intravital video microscopy, we directly observed the movements of cells in the microcirculation. Defining the molecular and physiologic mechanisms of lymphocyte migration into the inflammatory tissue has led to new approaches to the inhibition and augmentation of cell migration in vivo.

    Investigators

    • Rawn, James D., MD

    Trainees

    • Nezu, Kunimoto, MD
    • Ravnic, Dino, MD
    • Jiang, Xiaoqun, MD
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