• Researcher Profile

    Patrick Y. Wen, MD

     
    Director, Center for Neuro-Oncology
    Institute Physician


    Professor of Neurology, Harvard Medical School

    Center/Program

    Neuro-Oncology

    Office phone: 617-632-2166
    Fax: 617-632-4773

    Preferred contact method: appointment phone

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    Research Department

    Medical Oncology/Solid Tumor Oncology

    Interests

    Primary brain and spinal cord tumors including gliomas, glioblastoma, primary CNS lymphoma, and ependymoma, Neurologic complications in cancer patients, Brain and leptomeningeal metastases, Paraneoplastic syndromes

    Area of Research

    Novel Therapies For Adult Brain Tumors

    Dana-Farber Cancer Institute
    450 Brookline Avenue
    Shields Warren 430 D
    Boston, MA 02215

    Biography

    Dr. Wen graduated from the Medical College of St. Bartholomew's Hospital, University of London, in 1981. He completed his internal medicine training at the University of London postgraduate hospitals and his neurology residency in the Harvard-Longwood Neurology Training Program. His research is focused on novel treatments of brain tumors, especially targeted molecular agents. His other clinical interests include neurologic complications of cancer.

    Research

    Novel Therapies For Adult Brain Tumors

    The primary goal of our multidisciplinary group of investigators is to find more effective treatments for patients with brain tumors. Our program is especially interested in the development of novel targeted molecular therapies. We currently have a large number of clinical trials of these agents in progress. Recently we also started trials of combinations of targeted molecular agents, which are likely to be more effective than treatment with single agents alone. As part of these trials, we are also genotyping the tumors and correlating them with response to treatment in the hope of identifying subgroups of patients who are particularly likely to benefit. In addition, we are conducting clinical trials evaluating novel inhibitors of angiogenesis, chemotherapy combinations, intratumoral agents delivered by convection, and tumor vaccines.

    A second focus of our program is the development of novel therapies for meningiomas, brain metastases, and leptomeningeal metastases; clinical studies evaluating targeted molecular agents and novel chemotherapeutic agents against these cancers are under way. We also collaborate with colleagues in Pediatric Neuro-Oncology and the Department of Cancer Biology in a preclinical program directed at identifying novel targets for therapy and evaluating new agents for clinical trials.

    In addition, our program has a strong interest in quality-of-life issues affecting patients with brain tumors, in particular, venous thromboembolic disease. We are currently studying the molecular basis of venous thromboembolism and evaluating the benefit of prophylactic anticoagulation. Furthermore, we are about to begin studies evaluating the role of prophylactic anticonvulsants in patients with malignant glioma who have not had seizures and medications such as methylphenidate for radiation-induced fatigue.

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