• Researcher Profile

    Ramesh A. Shivdasani, MD, PhD

     
    Physician

    Professor of Medicine, Harvard Medical School

    Center/Program

    Gastrointestinal Cancer

    Office phone: 617-632-5746
    Fax: 617-582-7198

    Preferred contact method: office phone

    View Physician Profile
     
     

    Research Department

    Medical Oncology/Solid Tumor Oncology

    Interest

    Gastrointestinal cancers

    Area of Research

    Development and differentiation of the gastrointestinal epithelium; targeted molecular therapies.

    Dana-Farber Cancer Institute
    450 Brookline Avenue
    720
    Boston, MA 02215

    Biography

    Dr. Shivdasani received his medical and graduate degrees from The University of Michigan School in 1989. He completed his residency in Internal Medicine at Brigham and Women's Hospital, his fellowship in Medical Oncology at the Dana-Farber Cancer Institute, and post-doctoral research training at The Howard Hughes Medical Institute and Childrens Hospital Boston.

    In 1996, he joined the staff of Dana-Farber and Brigham and Women's Hospital, where he is a medical oncologist and laboratory investigator in the Gastrointestinal Cancer Center.

    Dr. Shivdasani's research focuses on normal mechanisms of development and cell differentiation in the gastrointestinal tract and new targets for treatment of intestinal tumors.

    Recent Awards

    • Association of American Physicians, 2009
    • American Society for Clinical Investigation, 2005
    • Harvard Medical School Class of 2007 teaching award, Best Tutor of the Year, 2004
    • Brian ODell Memorial Research Award (Leukemia & Lymphoma Society), 2003

    Research

    Development and differentiation of the gastrointestinal epithelium; targeted molecular therapies.

    Dr. Shivdasanis laboratory studies mechanisms of cell differentiation in the gastrointestinal epithelium. The research combines methods in molecular and cell biology with generation and analysis of genetically engineered mouse lines. The laboratory aims to elucidate and characterize genetic pathways that control differentiation of fetal and adult gastrointestinal epithelium.

    Present efforts include characterizing specific functions of the Wnt, Hedgehog and Notch signaling pathways and how these pathways intersect with tissue-restricted transcription factors.

    Dr. Shivdasani also directs a Translational Research laboratory that unites several Dana-Farber efforts in gastrointestinal cancers under a single umbrella. To acquire and exploit new molecular insights for biologically targeted cancer therapy, this laboratory investigates clinically annotated samples of gastric, colorectal and GI neuroendocrine tumors for polymorphisms, mutations and phenotypic alterations.

    Investigators

    • Kim, Byeong-Moo, PhD

    Trainees

    • Verzi, Michael, PhD
    • Kim, Tae-Hee, PhD
    • Ediger, Tracy, MD, PhD
    • Horst, David, MD
    • Sulahian, Rita, Ph.D.
    • Yadav, Vikas, Ph.D.
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